HCID 90308924, Verbindung → HCID 90309031, Verbindung
Reaktionsgleichung
[CH:1]1([C:4]2[C:12]3[C:8](=[CH:9][N:10]([CH3:13])[N:11]=3)[CH:7]=[C:6]([N+:14]([O-])=O)[CH:5]=2)[CH2:3][CH2:2]1>[Pd].C(OCC)(=O)C>[CH:1]1([C:4]2[C:12]3[C:8](=[CH:9][N:10]([CH3:13])[N:11]=3)[CH:7]=[C:6]([NH2:14])[CH:5]=2)[CH2:3][CH2:2]1Komponenten
4
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
10% Palladium on carbon (300 mg) was added to a solution of 7-cyclopropyl-2-methyl-5-nitro-2H-indazole obtained in the above-described Step 1 (311 mg) in ethyl acetate (5 mL) under nitrogen atmosphere, and the reaction solution was stirred under hydrogen atmosphere at room temperature overnight. The insolubles were filtrated, then the solvent was evaporated under vacuum, and the resultant residue was purified by column chromatography on silica gel (developing solvent:hexane/ethyl acetate) to obtain 7-cyclopropyl-2-methyl-2H-indazol-5-amine as brown amorphous.