Ammonium Hydroxide → 5-ethyl-1-methyl-1H-pyrazole-3-carboxamide
Reaktionsgleichung
[CH2:1]([C:3]1[N:7]([CH3:8])[N:6]=[C:5]([C:9]([O:11]CC)=O)[CH:4]=1)[CH3:2].[OH-].[NH4+:15]>>[CH2:1]([C:3]1[N:7]([CH3:8])[N:6]=[C:5]([C:9]([NH2:15])=[O:11])[CH:4]=1)[CH3:2]Komponenten
3
Versuchsvorschrift
A mixture of ethyl 5-ethyl-1-methyl-1H-pyrazole-3-carboxylate (5.03 g, 27.6 mmol) and ammonium hydroxide (28 mL of 30%) was stirred for 18 hours at ambient temperature. A precipitate formed, was isolated by filtration, and washed with cold hexanes to provide 2.60 g of 5-ethyl-1-methyl-1H-pyrazole-3-carboxamide as a white solid, mp 170-172° C.
Aufarbeitung
- customA precipitate formed
- customwas isolated by filtration
- washwashed with cold hexanes
Quellen und Nachweise
- ORD-Eintrag
- ord-0b90539ce36944738213eb0734ab4bd5
- Quelldatensatz
- uspto-grants-2015_09
- Patentnummer
- US09145410B2
Notizen zur Reaktion
Wird geladen…