Water → Ethyl (E)-3-{2-[(6,7-dimethoxy-4-quinolyl)oxy]-5-methoxyphenyl}-2-methyl-2-propenoate

Temperatur

0 °C

Sodium hydride (60 wt % oil, 52 mg) was dissolved in anhydrous tetrahydrofuran (1 ml), and a solution (0.5 ml) of triethyl 2-phosphonopropionate (119 mg) in tetrahydrofuran was added dropwise thereto under an argon atmosphere at 0° C. The mixture was stirred at 0° C. for 30 min, and a solution (0.5 ml) of 2-[(6,7-dimethoxy-4-quinolyl)oxy]-5-methoxybenzaldehyde (100 mg) in tetrahydrofuran was then added dropwise thereto. The reaction mixture was stirred at room temperature for one hr, and water (1 ml) was then added dropwise to stop the reaction. The mixture was extracted with ethyl acetate, and the ethyl acetate layer was then washed with water and saturated brine and was dried over anhydrous sodium sulfate. The solvent was removed therefrom by distillation under the reduced pressure, and the residue was purified by chromatography on silica gel using ethyl acetate-hexane for development to give the title compound (64 mg, yield 50%).

1. customat 0° C
2. stirringThe reaction mixture was stirred at room temperature for one hr
3. customthe reaction
4. extractionThe mixture was extracted with ethyl acetate
5. washthe ethyl acetate layer was then washed with water and saturated brine
6. dry with materialwas dried over anhydrous sodium sulfate
7. customThe solvent was removed
8. distillationby distillation under the reduced pressure
9. customthe residue was purified by chromatography on silica gel

ORD-Eintrag

ord-c1d11725a11e4f25a0434308d21929c7

Quelldatensatz

uspto-grants-2009_07

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07560558B2