(Pyrazin-2-yl)acetonitrile → HCID 136359207, Verbindung

HRID 2286259Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2286259
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[CH2:7][C:8]#[N:9].[N:10]([O-])=[O:11].[Na+]>C(O)(=O)C>[OH:11][N:10]=[C:7]([C:2]1[CH:3]=[N:4][CH:5]=[CH:6][N:1]=1)[C:8]#[N:9]

Komponenten

4

Edukt 2

HCID 12782906(Pyrazin-2-yl)acetonitrileHCID 23668193Sodium Nitrite

Produkt 1

HCID 136359207HCID 136359207, VerbindungAusbeute 88 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

Pyrazineacetonitrile (32 g), prepared as described in British Patent Specification No. 1 021 397, was dissolved in glacial acetic acid (250 ml). The solution was stirred and 1.2 equivalents of sodium nitrite (22.3 g) were added in small portions, while the temperature was kept under 20° C. After the addition, the reaction mixture was stirred at room temperature for another two hours. The title compound separated partly from the reaction mixture. On evaporation of the solvent under reduced pressure, a solid was obtained which on recrystallization from hot water yielded α-hydroxyiminopyrazineacetonitrile (35 g, 88%). Melting point >192° C. (dec.).

Aufarbeitung

  1. customwas kept under 20° C
  2. additionAfter the addition
  3. stirringthe reaction mixture was stirred at room temperature for another two hours
  4. customThe title compound separated partly from the reaction mixture
  5. customOn evaporation of the solvent under reduced pressure
  6. customa solid was obtained which
  7. customon recrystallization from hot water

Quellen und Nachweise

ORD-Eintrag
ord-ba42fb78d84b4530927d9718759347b2
Quelldatensatz
uspto-grants-1982_04
Patentnummer
US04327213

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