Hydrochloric Acid → 2-(((5-Methyl-1H-imidazol-4-yl)methyl)thio)ethylamine dihydrochloride

HRID 2286742Notizen

Reaktionsgleichung

CN[CH2:3][C:4]1[N:5]=[CH:6][NH:7][C:8]=1[CH3:9].C(N)CCC.C(NCCCC)CCC.C(NCC1N=CNC=1C)CCC.C(N(CC1N=CNC=1C)CCCC)CCC.[NH2:52][CH2:53][CH2:54][SH:55].[ClH:56]>>[ClH:56].[ClH:56].[NH2:52][CH2:53][CH2:54][S:55][CH2:3][C:4]1[N:5]=[CH:6][NH:7][C:8]=1[CH3:9]

Komponenten

Edukt 7

HCID 313Hydrochloric Acid

HCID 6058Cysteamine

HCID 8007Butylamine

HCID 8148Dibutylamine

HCID 13316650n-Methyl-1-(4-methyl-1h-imidazol-5-yl)methanamine

HCID 234621284-(N-butylaminomethyl)-5-methylimidazole

HCID 234621524-(N,N-dibutylaminomethyl)-5-methylimidazole

Produkt 1

HCID 30159992-(((5-Methyl-1H-imidazol-4-yl)methyl)thio)ethylamine dihydrochloride

Versuchsvorschrift

By the same procedure, using methylene in place of dimethylamine, 4-(N-methylaminomethyl)-5-methylimidazole is prepared. In the same way, using butylamine and dibutylamine, 4-(N-butylaminomethyl)-5-methylimidazole and 4-(N,N-dibutylaminomethyl)-5-methylimidazole are prepared. Refluxing these intermediates with cysteamine by the above procedure and treating with hydrochloric acid gives 4-(2-aminoethyl)thiomethyl-5-methylimidazole dihydrochloride.

Aufarbeitung

customis prepared
customare prepared

Quellen und Nachweise

ORD-Eintrag: ord-4994af41f0fa44a19c02c3144c0bcce2
Quelldatensatz: uspto-grants-1981_05
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04267337

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