Bromine → 2-Bromo-5,6-dimethoxy-3-methylbenzene-1,4-diol

HRID 2287258Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2287258
[Br:1]Br.[CH3:3][O:4][C:5]1[C:11]([O:12][CH3:13])=[C:10]([OH:14])[C:9]([CH3:15])=[CH:8][C:6]=1[OH:7]>C(Cl)(Cl)Cl>[CH3:3][O:4][C:5]1[C:11]([O:12][CH3:13])=[C:10]([OH:14])[C:9]([CH3:15])=[C:8]([Br:1])[C:6]=1[OH:7]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 111830272,3-Dimethoxy-5-methyl-1,4-benzenediol

Produkt 1

HCID 127215532-Bromo-5,6-dimethoxy-3-methylbenzene-1,4-diolAusbeute 100,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel2×

Versuchsvorschrift

A solution of 39.5 g of bromine in 70 ml of chloroform was added dropwise at about 5° C. to a solution of 46.0 g of 2,3-dimethoxy-5-methylhydroquinone in 500 ml of chloroform, under a nitrogen atmosphere. Stirring was continued at the same temperature for 3 hours, and then the reaction mixture was washed with water until the washings were colorless. The organic layer was dried over magnesium sulfate, and the solvent was distilled off under reduced pressure to provide 65.5 g of 2,3-dimethoxy-5-methyl-6-bromohydroquinone.

Aufarbeitung

  1. washthe reaction mixture was washed with water until the washings
  2. dry with materialThe organic layer was dried over magnesium sulfate
  3. distillationthe solvent was distilled off under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-883910633b4440c3995129d0be420811
Quelldatensatz
uspto-grants-1981_05
Patentnummer
US04270003

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