Sodium Hydroxide → 5-Cyano-2-iodobenzoic acid

HRID 2287346Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2287346
[OH-].[Na+].C[O:4][C:5](=[O:15])[C:6]1[CH:11]=[C:10]([C:12]#[N:13])[CH:9]=[CH:8][C:7]=1[I:14]>O.CO>[I:14][C:7]1[CH:8]=[CH:9][C:10]([C:12]#[N:13])=[CH:11][C:6]=1[C:5]([OH:15])=[O:4]

Komponenten

5

Edukt 2

HCID 14798Sodium HydroxideHCID 23076822Methyl 5-cyano-2-iodobenzoate

Produkt 1

HCID 220088225-Cyano-2-iodobenzoic acidAusbeute 66,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of sodium hydroxide (0.44 g, 11 mmol) in water (10 ml) was added to 2-iodo-5-cyanobenzoic acid methyl ester (2.7 g, 9.4 mmol) in methanol. The mixture was stirred for 20 h, then most of the solvent was evaporated and the residue acidified with 2N hydrochloric acid. The resulting precipitate was filtered off and dried to give a white solid (1.7 g). MS (-CI) m /z 272 [M-H]+.

Aufarbeitung

  1. custommost of the solvent was evaporated
  2. filtrationThe resulting precipitate was filtered off
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-2264b98e007e4a1daf8e6345d8bb6f21
Quelldatensatz
uspto-grants-2000_07
Patentnummer
US06083952

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