(4,5-Dimethylfuran-2-yl)-(4,5-dimethylthiazol-2-yl)methanol → (4,5-Dimethylfuran-2-yl)(4,5-dimethylthiazol-2-yl)-methanone

HRID 228796

Reaktionsgleichung

Reaktionsgleichung von HRID 228796
[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]([C:10]2[S:11][C:12]([CH3:16])=[C:13]([CH3:15])[N:14]=2)[OH:9])[O:5][C:6]=1[CH3:7]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[S:11][C:12]([CH3:16])=[C:13]([CH3:15])[N:14]=2)=[O:9])[O:5][C:6]=1[CH3:7]

Komponenten

4

Edukt 1

HCID 23078354(4,5-Dimethylfuran-2-yl)-(4,5-dimethylthiazol-2-yl)methanol

Produkt 1

HCID 23078247(4,5-Dimethylfuran-2-yl)(4,5-dimethylthiazol-2-yl)-methanoneAusbeute 97,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 6212ChloroformLösungsmittel

Versuchsvorschrift

(4,5-Dimethylfuran-2-yl)-(4,5-dimethylthiazol-2-yl)methanol (945 mg) was dissolved in chloroform (20 ml) to prepare a solution. Manganese dioxide (3.5 g) was added to the solution, and the mixture was stirred at room temperature overnight. The reaction solution was filtered through Celite, and the solvent was removed from the filtrate by distillation under the reduced pressure to give (4,5-dimethylfuran-2-yl)(4,5-dimethylthiazol-2-yl)-methanone (910 mg, yield 97%).

Aufarbeitung

  1. customto prepare a solution
  2. filtrationThe reaction solution was filtered through Celite
  3. customthe solvent was removed from the filtrate by distillation under the reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-ff9c0126c13c495080a3055c9946dee9
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07560558B2

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