(4,5-Dimethylfuran-2-yl)-(6-methyl-pyridin-2-yl)-methanol → (4,5-Dimethylfuran-2-yl)-(6-methyl-pyridin-2-yl)methanone

HRID 228818

Reaktionsgleichung

Reaktionsgleichung von HRID 228818
[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[N:11]=2)[OH:9])[O:5][C:6]=1[CH3:7]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[N:11]=2)=[O:9])[O:5][C:6]=1[CH3:7]

Komponenten

4

Edukt 1

HCID 23078353(4,5-Dimethylfuran-2-yl)-(6-methyl-pyridin-2-yl)-methanol

Produkt 1

HCID 23078390(4,5-Dimethylfuran-2-yl)-(6-methyl-pyridin-2-yl)methanoneAusbeute 58,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysator2×HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

(4,5-Dimethylfuran-2-yl)-(6-methyl-pyridin-2-yl)-methanol (1.4 g) was dissolved in chloroform (30 ml) to prepare a solution. Manganese dioxide (5.7 g) was added to the solution, and the mixture was stirred at room temperature overnight. Further, manganese dioxide (1.8 g) was then added thereto, and the mixture was stirred overnight. The reaction solution was filtered through Celite. The solvent was removed from the filtrate by distillation under the reduced pressure to give (4,5-dimethylfuran-2-yl)-(6-methyl-pyridin-2-yl)-methanone (815 mg, yield 58%).

Aufarbeitung

  1. customto prepare a solution
  2. stirringthe mixture was stirred overnight
  3. filtrationThe reaction solution was filtered through Celite
  4. customThe solvent was removed from the filtrate by distillation under the reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-6ab18d8b261b491b95b95d5380da68f3
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07560558B2

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