Water → 3-(1-Methyl-1H-pyrazol-4-yl)propan-1-ol

HRID 2288223Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2288223
[CH3:1][N:2]1[CH:6]=[C:5]([CH2:7][CH2:8][C:9](OCC)=[O:10])[CH:4]=[N:3]1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O.[OH-].[Na+]>O1CCCC1>[CH3:1][N:2]1[CH:6]=[C:5]([CH2:7][CH2:8][CH2:9][OH:10])[CH:4]=[N:3]1

Komponenten

6

Edukt 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 18703402Ethyl 3-(1-methyl-1h-pyrazol-4-yl)propanoateHCID 21226445Aluminium lithium hydride

Produkt 1

HCID 188014053-(1-Methyl-1H-pyrazol-4-yl)propan-1-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To an ice-cooled solution of ethyl 3-(1-methyl-1H-pyrazol-4-yl)propionate (1.05 g) in tetrahydrofuran (10 ml) was added lithium aluminum hydride (0.22 g) under nitrogen atmosphere After the mixture was stirred for 30 minutes, water and 15% sodium hydroxide aqueous solution were added successively to the mixture. The resulting precipitates were filtered off through Celite® pad and the filtrate was extracted with ethyl acetate. The organic layer was washed with water, dried over magnesium sulfate and concentrated under reduced pressure to give 3-(1-methyl-1H-pyrazol-4-yl)-1-propanol.

Aufarbeitung

  1. customThe resulting precipitates
  2. filtrationwere filtered off through Celite® pad
  3. extractionthe filtrate was extracted with ethyl acetate
  4. washThe organic layer was washed with water
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-1365775ca0334409a57305cc96abcc04
Quelldatensatz
uspto-grants-2000_07
Patentnummer
US06087357

Notizen zur Reaktion

Wird geladen…