Sodium methanethiolate → 7-Pyridin-2-yl-isoquinolin-6-ol
Reaktionsgleichung
C[O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=1)[CH:9]=[N:8][CH:7]=[CH:6]2.C[S-].[Na+]>CN(C)C=O>[N:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[C:12]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[CH:9]2)=[CH:4][C:3]=1[OH:2]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 150 °C
Versuchsvorschrift
6-Methoxy-7-pyridin-2-yl-isoquinoline (118 mg) and sodium thiomethoxide (350 mg) were suspended in N,N-dimethylformamide (3 ml), and the mixture was stirred at 150° C. for 4 hr. The reaction solution was cooled to room temperature, the reaction solution was then filtered, and the solvent was removed from the filtrate by distillation under the reduced pressure. The residue was purified by thin layer chromatography using chloroform-methanol to give 7-pyridin-2-yl-isoquinolin-6-ol (30 mg, yield 27%).
Aufarbeitung
- temperatureThe reaction solution was cooled to room temperature
- filtrationthe reaction solution was then filtered
- customthe solvent was removed from the filtrate by distillation under the reduced pressure
- customThe residue was purified by thin layer chromatography
Quellen und Nachweise
- ORD-Eintrag
- ord-8075445007724bd081b256dfd0c1cf0e
- Quelldatensatz
- uspto-grants-2009_07
- Patentnummer
- US07560558B2
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