Oxalyl chloride → 1,4-Dichloro-7-isoquinolinecarbonyl chloride

HRID 2289819Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2289819
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[Cl:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=C(C(O)=O)[CH:16]=2)[C:11]([Cl:21])=[CH:10][N:9]=1>C(Cl)Cl.CN(C=O)C>[Cl:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[C:1]([C:2]([Cl:4])=[O:3])[CH:16]=2)[C:11]([Cl:21])=[CH:10][N:9]=1

Komponenten

5

Edukt 2

HCID 65578Oxalyl chlorideHCID 186982431,4-Dichloro-7-isoquinolinecarboxylic acid

Produkt 1

HCID 186981881,4-Dichloro-7-isoquinolinecarbonyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Anal. Found: C, 49.59; H, 2.08; N, 5.74. Calc for C10H5Cl2NO2 : C, 49.62; H, 2.08; N, 5.78. ##STR170## Oxalyl chloride (144 μL, 1.65 mmol) was added to a suspension of 1,4-dichloro-7-isoquinolinecarboxylic acid (200 mg, 0.83 mmol) at room temperature in CH2Cl2 (10 mL), followed by DMF (1 drop). After 30 min the resultant clear solution was evaporated in vacuo to afford 1,4-dichloro-7-isoquinolinecarbonyl chloride which was used without further purification.

Aufarbeitung

  1. customAfter 30 min the resultant clear solution was evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-e008b04eccea4bfc9ff503e33b0eebc9
Quelldatensatz
uspto-grants-2000_07
Patentnummer
US06093731

Notizen zur Reaktion

Wird geladen…