Methanethiol → {3-[(4-Methoxyphenyl)methyl]-1,3-thiazolidin-2-ylidene}cyanamide

HRID 2290260Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2290260
CS(=[N:7][C:8]#[N:9])C(=S)OC.[CH3:10][O:11][C:12]1[CH:22]=[CH:21][C:15]([CH2:16][NH:17][CH2:18][CH2:19][SH:20])=[CH:14][CH:13]=1.[CH3:23]S>C(O)C>[C:8]([N:7]=[C:23]1[N:17]([CH2:16][C:15]2[CH:21]=[CH:22][C:12]([O:11][CH3:10])=[CH:13][CH:14]=2)[CH2:18][CH2:19][S:20]1)#[N:9]

Komponenten

5

Edukt 3

HCID 878MethanethiolHCID 14306201N-(4-methoxybenzyl)-cysteamineHCID 87522899Cyanimino-dithiocarbonic acid dimethylester

Produkt 1

HCID 14306204{3-[(4-Methoxyphenyl)methyl]-1,3-thiazolidin-2-ylidene}cyanamideAusbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

3.65 g (23.5 moles) of cyanimino-dithiocarbonic acid dimethylester (purity: 94%) and 5.91 (30 moles) of N-(4-methoxybenzyl)-cysteamine are boiled in 30 ml of ethanol until the evolution of methyl mercaptan terminates. The reaction mixture is evaporated and the crystalline residue is recrystallized from 15 ml of isopropanol. 5.35 g (92%) of 2-cyanimino-3-(4-methoxybenzyl)-thiazolidine are obtained, melting at 99° to 102° C.

Aufarbeitung

  1. customThe reaction mixture is evaporated
  2. customthe crystalline residue is recrystallized from 15 ml of isopropanol

Quellen und Nachweise

ORD-Eintrag
ord-da11e47810b3438c9a5b4916232a9061
Quelldatensatz
uspto-grants-1986_10
Patentnummer
US04616025

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