4-Chlorobenzoyl chloride → Methyl 4-[1-(4-chlorobenzoyl)-piperazin-4-ylmethyl]-benzoate

HRID 2290453

Reaktionsgleichung

Reaktionsgleichung von HRID 2290453
[N:1]1([CH2:7][C:8]2[CH:17]=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:9]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[Cl:18][C:19]1[CH:27]=[CH:26][C:22]([C:23](Cl)=[O:24])=[CH:21][CH:20]=1>N1C=CC=CC=1>[Cl:18][C:19]1[CH:27]=[CH:26][C:22]([C:23]([N:4]2[CH2:5][CH2:6][N:1]([CH2:7][C:8]3[CH:17]=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:9]=3)[CH2:2][CH2:3]2)=[O:24])=[CH:21][CH:20]=1

Komponenten

4

Edukt 2

HCID 85014-Chlorobenzoyl chlorideHCID 7018627Methyl 4-[(piperazin-1-yl)methyl]benzoate

Produkt 1

HCID 54279459Methyl 4-[1-(4-chlorobenzoyl)-piperazin-4-ylmethyl]-benzoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

To a solution of 15.3 g. (50 mmole) methyl 4-(piperazin-1-ylmethyl)-benzoate and 175 ml. anhydrous pyridine, there is added dropwise, at 0°-5° C., 8.7 g. (50 mmole) 4-chlorobenzoyl chloride and the reaction mixture kept for a further hour at 0° to 5° C., then overnight at 20° C. The reaction mixture is stirred into ice water and the precipitated product is filtered off with suction, washed with water and dried to give 18.5 g. (quantitative) of the desired product; m.p. 134°-135° C.

Aufarbeitung

  1. customovernight
  2. customat 20° C
  3. filtrationthe precipitated product is filtered off with suction
  4. washwashed with water
  5. customdried
  6. customto give 18.5 g

Quellen und Nachweise

ORD-Eintrag
ord-6dc8888c09b34dc5bb0d689ff177e249
Quelldatensatz
uspto-grants-1986_10
Patentnummer
US04616086

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