(4,5-Dimethylfuran-2-yl)-(3-methylpyridin-2-yl)-methanol → (4,5-Dimethylfuran-2-yl)-(3-methylpyridin-2-yl)-methanone

HRID 229049

Reaktionsgleichung

Reaktionsgleichung von HRID 229049
[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]([C:10]2[C:15]([CH3:16])=[CH:14][CH:13]=[CH:12][N:11]=2)[OH:9])[O:5][C:6]=1[CH3:7]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[C:15]([CH3:16])=[CH:14][CH:13]=[CH:12][N:11]=2)=[O:9])[O:5][C:6]=1[CH3:7]

Komponenten

4

Edukt 1

HCID 23078465(4,5-Dimethylfuran-2-yl)-(3-methylpyridin-2-yl)-methanol

Produkt 1

HCID 23078529(4,5-Dimethylfuran-2-yl)-(3-methylpyridin-2-yl)-methanoneAusbeute 81,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 6212ChloroformLösungsmittel

Versuchsvorschrift

(4,5-Dimethylfuran-2-yl)-(3-methylpyridin-2-yl)-methanol (1.17 g) was dissolved in chloroform (30 ml) to prepare a solution. Manganese dioxide (4.69 g) was added to the solution, and the mixture was stirred at room temperature overnight. The reaction solution was filtered through Celite, and the solvent was removed from the filtrate by distillation under the reduced pressure to give (4,5-dimethylfuran-2-yl)-(3-methylpyridin-2-yl)-methanone (940 mg, yield 81%).

Aufarbeitung

  1. customto prepare a solution
  2. filtrationThe reaction solution was filtered through Celite
  3. customthe solvent was removed from the filtrate by distillation under the reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-d541dd2f8c2b40be824318bccb382ad9
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07560558B2

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