Water → 2-Fluoro-1-(methylsulfonyl)-4-nitrobenzene

HRID 22907

Reaktionsgleichung

Reaktionsgleichung von HRID 22907
[F:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1F.[CH3:12][S:13]([O-:15])=[O:14].[Na+].O>CS(C)=O>[F:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1[S:13]([CH3:12])(=[O:15])=[O:14]

Komponenten

5

Edukt 3

HCID 962WaterHCID 1230531,2-Difluoro-4-nitrobenzeneHCID 2733271Sodium methanesulfinate

Produkt 1

HCID 223167812-Fluoro-1-(methylsulfonyl)-4-nitrobenzeneAusbeute 79 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

8 g of 3,4-difluoronitrobenzene and 1.01 eq of sodium methanesulfinate (95%) was dissolved in 10 ml of DMSO. The solution was stirred at 60° C. for 3 hours. When the reaction was completed, the solution was added to 100 ml of water to form pale yellow solid, followed by filtration and washing with 50 ml of cool water and 30 ml of n-hexane separately to give 8.8 g of the title compound as a pale yellow solid (yield 79%).

Aufarbeitung

  1. customto form pale yellow solid
  2. filtrationfollowed by filtration
  3. washwashing with 50 ml of cool water and 30 ml of n-hexane separately

Quellen und Nachweise

ORD-Eintrag
ord-d65540f051e14807a858c381dcb08832
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06849652B1

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