Sodium borohydride → 7-Bromo-1,2,3,4-tetrahydro-3,3-dimethyl-1-naphthalenol

HRID 2292041Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2292041
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][C:7]([CH3:14])([CH3:13])[CH2:8][C:9]2=[O:12])=[CH:4][CH:3]=1.[BH4-].[Na+]>C(O)C>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][C:7]([CH3:14])([CH3:13])[CH2:8][CH:9]2[OH:12])=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 4311764Sodium borohydrideHCID 157119867-broMo-3,3-diMethyl-3,4-dihydronaphthalen-1(2H)-one

Produkt 1

HCID 148194057-Bromo-1,2,3,4-tetrahydro-3,3-dimethyl-1-naphthalenolAusbeute 89 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 7-bromo-3,3-dimethyl-3,4-dihydro-1(2H)-naphthalenone (7.8 g) in dry ethanol (50 ml) at 0° C., was treated with sodium borohydride (1.5 g). The mixture was stirred and allowed to warm to room temperature over 18 hours, and the ethanol removed in vacuo. The residue was partitioned between ethyl acetate and water, and the organic layers were dried and evaporated to give the alcohol as a gum (7.0 g)

Aufarbeitung

  1. customthe ethanol removed in vacuo
  2. customThe residue was partitioned between ethyl acetate and water
  3. customthe organic layers were dried
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-967ecdb79aab45dca56c6e3262654798
Quelldatensatz
uspto-grants-1989_01
Patentnummer
US04800212

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