Phenol → Phenyl phenylacetate

HRID 2292121Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2292121
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:8]1([CH2:14][C:15](Cl)=[O:16])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>ClCCl.N1C=CC=CC=1>[C:8]1([CH2:14][C:15]([O:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[O:16])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Komponenten

5

Edukt 2

HCID 996PhenolHCID 7679Phenylacetyl chloride

Produkt 1

HCID 164721Phenyl phenylacetateAusbeute 95,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1049PyridineLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Phenol (47.9 g) was dissolved in dichloromethane (250 ml) and pyridine (44.3 g). Phenylacetyl chloride (78.8 g) was added with stirring over 40 min., and the resulting mixture allowed to stand at room temperature for 1 hr. The mixture was washed sequentially with water, twice with dilute hydrochloric acid, once with dilute sodium hydroxide solution, and then once with saturated brine. The solution was dried and evaporated to give phenyl phenylacetate 103.3 g., m.pt 39°-41°.

Aufarbeitung

  1. waitto stand at room temperature for 1 hr
  2. washThe mixture was washed sequentially with water, twice with dilute hydrochloric acid, once with dilute sodium hydroxide solution
  3. customThe solution was dried
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-021f2ec649524e079520067619bd1e06
Quelldatensatz
uspto-grants-1989_01
Patentnummer
US04801593

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