4-Acetoxy-3,5-bis[N,N-bis(t-butoxycarbonylmethyl)aminomethyl]-3'-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo-beta-methoxycarbonylphenethyl]benzophenone → 3,5-bis[N,N-bis(carboxymethyl)aminomethyl]-4-hydroxy-3'-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo-beta-methoxycarbonylphenethyl]benzophenone

HRID 2292323

Reaktionsgleichung

Reaktionsgleichung von HRID 2292323
C([O:4][C:5]1[C:42]([CH2:43][N:44]([CH2:53][C:54]([O:56]C(C)(C)C)=[O:55])[CH2:45][C:46]([O:48]C(C)(C)C)=[O:47])=[CH:41][C:8]([C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([CH2:17][CH:18]([C:37]([O:39][CH3:40])=[O:38])[C:19]3[CH:24]=[C:23]([I:25])[C:22]([O:26][C:27]4[CH:32]=[C:31]([I:33])[C:30]([OH:34])=[C:29]([I:35])[CH:28]=4)=[C:21]([I:36])[CH:20]=3)[CH:12]=2)=[O:10])=[CH:7][C:6]=1[CH2:61][N:62]([CH2:71][C:72]([O:74]C(C)(C)C)=[O:73])[CH2:63][C:64]([O:66]C(C)(C)C)=[O:65])(=O)C>FC(F)(F)C(O)=O.O>[C:64]([CH2:63][N:62]([CH2:61][C:6]1[CH:7]=[C:8]([CH:41]=[C:42]([CH2:43][N:44]([CH2:53][C:54]([OH:56])=[O:55])[CH2:45][C:46]([OH:48])=[O:47])[C:5]=1[OH:4])[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([CH2:17][CH:18]([C:37]([O:39][CH3:40])=[O:38])[C:19]2[CH:24]=[C:23]([I:25])[C:22]([O:26][C:27]3[CH:32]=[C:31]([I:33])[C:30]([OH:34])=[C:29]([I:35])[CH:28]=3)=[C:21]([I:36])[CH:20]=2)[CH:12]=1)=[O:10])[CH2:71][C:72]([OH:74])=[O:73])([OH:66])=[O:65]

Komponenten

4

Edukt 1

HCID 867415754-Acetoxy-3,5-bis[N,N-bis(t-butoxycarbonylmethyl)aminomethyl]-3'-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo-beta-methoxycarbonylphenethyl]benzophenone

Produkt 1

HCID 538207413,5-bis[N,N-bis(carboxymethyl)aminomethyl]-4-hydroxy-3'-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo-beta-methoxycarbonylphenethyl]benzophenone

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

A solution of 630 mg of 21 in 5 mL of trifluoroacetic acid was stirred overnight, diluted with water and the solid which separated was collected and dried; yield 550 mg. The field desorption mass spectrum showed 22 (m/e1305) is present, as well as some material in which the methyl ester of the thyroxine has been hydrolyzed to the acid.

Aufarbeitung

  1. customthe solid which separated
  2. customwas collected
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-8a7b1a651baa4cb6b892f66da1eb9a84
Quelldatensatz
uspto-grants-1989_01
Patentnummer
US04801722

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