Aluminium lithium hydride → 3-(8-Phenyloctyloxy)-2-hydroxypropylamine

HRID 2294333

Reaktionsgleichung

Reaktionsgleichung von HRID 2294333
[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][O:15][CH2:16][CH:17]([OH:22])[CH2:18][N:19]=[N+]=[N-])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][O:15][CH2:16][CH:17]([OH:22])[CH2:18][NH2:19])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

4

Edukt 2

HCID 21226445Aluminium lithium hydrideHCID 214747133-(8-Phenyloctyloxy)-2-hydroxypropylazide

Produkt 1

HCID 214747293-(8-Phenyloctyloxy)-2-hydroxypropylamineAusbeute 88,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A procedure similar to that described in Preparation 13 was repeated, except that 2.6 g of 3-(8-phenyloctyloxy)-2-hydroxypropylazide (Prepared as described in Preparation 65), 0.65 g of lithium aluminum hydride and 80 ml of anhydrous tetrahydrofuran were used, to give 2.11 g of the title compound, melting at 50° C. to 54° C.

Aufarbeitung

  1. customA procedure similar to that described in Preparation 13

Quellen und Nachweise

ORD-Eintrag
ord-28d42f0748f2475fa50735ed7cb36052
Quelldatensatz
uspto-grants-1997_11
Patentnummer
US05688823

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