Hydrochloric Acid → HCID 10615215, Verbindung

HRID 2294795

Reaktionsgleichung

Reaktionsgleichung von HRID 2294795
[C:1]1([N:7]2[CH2:11][C:10](=[O:12])[NH:9][C:8]2=[O:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:14][C:15]1[CH:23]=[CH:22][C:18]([C:19](Cl)=[O:20])=[CH:17][CH:16]=1.Cl>N1C=CC=CC=1>[Cl:14][C:15]1[CH:23]=[CH:22][C:18]([C:19]([N:9]2[C:10](=[O:12])[CH2:11][N:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[C:8]2=[O:13])=[O:20])=[CH:17][CH:16]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 85014-Chlorobenzoyl chlorideHCID 5705761-Phenylimidazolidine-2,4-dione

Produkt 1

HCID 10615215HCID 10615215, VerbindungAusbeute 25 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

In accordance with the synthesis process (B), 500 mg (2.84 mmol) of 1-phenyl-imidazolidin-2,4-dione were dissolved in 20 ml of pyridine. To the solution, 500 mg (2.86 mmol) of p-chlorobenzoyl chloride were added dropwise while chilling with ice water. The resultant mixture was stirred at 0°-5° C. for 2 hours, and dilute hydrochloric acid was then added to the reaction mixture. Crystals deposited were collected by filtration by means of suction. These crude crystals were recrystallized from n-hexane/ethyl acetate, thereby obtaining 220 mg (yield: 25%) of the title compound.

Aufarbeitung

  1. filtrationCrystals deposited were collected by filtration by means of suction
  2. customThese crude crystals were recrystallized from n-hexane/ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-f577291978ed42e0888b32ff3e3c797c
Quelldatensatz
uspto-grants-1997_11
Patentnummer
US05691335

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