L-Methionine → HCID 13316871, Verbindung

HRID 2295515Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2295515
[C:1]([S:4][CH2:5][CH2:6][C:7]([N:9]1[C@H:13]([C:14]([OH:16])=O)[CH2:12][S:11][C@@H:10]1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[OH:23])=[O:8])(=[O:3])[CH3:2].CN1CCOCC1.C(Cl)(=O)OCC(C)C.[NH2:39][C@H:40]([C:45]([OH:47])=[O:46])[CH2:41][CH2:42][S:43][CH3:44]>C1COCC1>[C:1]([S:4][CH2:5][CH2:6][C:7]([N:9]1[C@H:13]([C:14]([NH:39][C@H:40]([C:45]([OH:47])=[O:46])[CH2:41][CH2:42][S:43][CH3:44])=[O:16])[CH2:12][S:11][C@@H:10]1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[OH:23])=[O:8])(=[O:3])[CH3:2]

Komponenten

6

Edukt 4

HCID 6137L-MethionineHCID 79724-Methylmorpholine2×HCID 62365Isobutyl chloroformateHCID 13316857HCID 13316857, Verbindung

Produkt 1

HCID 13316871HCID 13316871, VerbindungAusbeute 66 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

The suspension of mixed anhydride in THF is prepared by using 5.3 g of (2R,4R)-3-(S-acetyl-3-mercaptopropanoyl)-2-(2-hydroxyphenyl)-4-thiazolidinecarboxylic acid, 1.5 g of N-methylmorpholine and 2.0 g of isobutyl chlorocarbonate. To the suspension the aqueous solution of 4.5 g of L-methionine and 3.0 g of N-methylmorpholine is added, and treated in the same manner as Example 1 to give 1.6 g (66%) of the titled compound.

Aufarbeitung

  1. customis prepared
  2. additiontreated in the same manner as Example 1

Quellen und Nachweise

ORD-Eintrag
ord-15b4392de585466a8a1c07755f14692a
Quelldatensatz
uspto-grants-1984_01
Patentnummer
US04425333

Notizen zur Reaktion

Wird geladen…