Water → 1-Benzoyl-3-[1-(4-isopropylbenzyl)piperid-4-yl]urea

HRID 2295772

Reaktionsgleichung

Reaktionsgleichung von HRID 2295772
[CH:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8]Cl)=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[C:12]([NH:20][C:21](=[O:29])[NH:22][CH:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1)(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(N(CC)CC)C.O>CN(C)C=O>[C:12]([NH:20][C:21]([NH:22][CH:23]1[CH2:28][CH2:27][N:26]([CH2:8][C:7]2[CH:10]=[CH:11][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:5][CH:6]=2)[CH2:25][CH2:24]1)=[O:29])(=[O:19])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 8471TriethylamineHCID 749164-Isopropylbenzyl chlorideHCID 126085824-Benzoylureidopiperidine

Produkt 1

HCID 129423021-Benzoyl-3-[1-(4-isopropylbenzyl)piperid-4-yl]urea

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

4-Isopropylbenzyl chloride (0.84 g, 0.005 m), 4-benzoylureidopiperidine (1.28 g, 0.005 m) and triethylamine (0.6 g) in dimethylformamide (25 cm3) were stirred at room temperature for 24 hours. Water was added and the precipitated solid filtered off. The solid was suspended in isopropylalcohol and acidified with ethanolic HCl. The title compound was filtered off and dried (1.2 g), m.p. 240°-242° C. as the hydrochloride salt, hemihydrate.

Aufarbeitung

  1. filtrationthe precipitated solid filtered off
  2. filtrationThe title compound was filtered off
  3. dry with materialdried (1.2 g), m.p. 240°-242° C. as the hydrochloride salt, hemihydrate

Quellen und Nachweise

ORD-Eintrag
ord-bef9fd749ec94b95807a0c96a43fc4d2
Quelldatensatz
uspto-grants-1984_01
Patentnummer
US04426387

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