Morpholine → HCID 9894980, Verbindung
Reaktionsgleichung
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[NH2:7][C:8]1[N:13]=[C:12]([NH:14][CH2:15][CH2:16][NH:17][C:18]2[N:23]=[C:22]([C:24]3[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][C:25]=3[Cl:31])[C:21]([N:32]3[C:36](=[O:37])[CH:35]=[CH:34][C:33]3=[O:38])=[CH:20][N:19]=2)[CH:11]=[CH:10][C:9]=1[N+:39]([O-:41])=[O:40]>>[NH2:7][C:8]1[N:13]=[C:12]([NH:14][CH2:15][CH2:16][NH:17][C:18]2[N:23]=[C:22]([C:24]3[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][C:25]=3[Cl:31])[C:21]([N:32]3[C:36](=[O:37])[CH2:35][CH:34]([N:1]4[CH2:6][CH2:5][O:4][CH2:3][CH2:2]4)[C:33]3=[O:38])=[CH:20][N:19]=2)[CH:11]=[CH:10][C:9]=1[N+:39]([O-:41])=[O:40]Komponenten
3
Versuchsvorschrift
Large excess of morpholine was added to clean fractions of 1-[2-({2-[(6-amino-5-nitro(2-pyridyl))amino]ethyl}amino)-4-(2,4-dichlorophenyl)pyrimidin-5-yl]-3-pyrroline-2,5-dione concentrated in vacuo, and purified by column chromatography eluting with 5-10% methanol/methylene chloride to obtain 1-[2({2-[(6-amino-5-nitro(2-pyridyl))amino]ethyl}amino)-4-(2,4-dichlorophenyl)pyrimidin-5-yl]-3-morpholin-4-ylpyrrolidine-2,5-dione.
Aufarbeitung
- concentrationconcentrated in vacuo