Morpholine → 2-(morpholin-4-yl)-4-nitro-1H-benzimidazole

HRID 2298812Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2298812
Cl[C:2]1[NH:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([N+:11]([O-:13])=[O:12])[C:4]=2[N:3]=1.[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1.C(=O)([O-])O.[Na+]>>[N:14]1([C:2]2[NH:6][C:5]3[CH:7]=[CH:8][CH:9]=[C:10]([N+:11]([O-:13])=[O:12])[C:4]=3[N:3]=2)[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1

Komponenten

4

Edukt 3

HCID 8083MorpholineHCID 516892Sodium BicarbonateHCID 14765451HCID 14765451, Verbindung

Produkt 1

HCID 183786202-(morpholin-4-yl)-4-nitro-1H-benzimidazole

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

A mixture of 2-chloro-4-nitro-1H-benzimidazole (300 mg) and morpholine (1 ml) was stirred at 50° C. for 8 hours. The reaction mixture was poured into saturated aqueous sodium hydrogencarbonate solution and extracted with chloroform. The organic layer was washed with brine, and dried over magnesium sulfate. The solvent was evaporated in vacuo. The residue was washed with isopropyl ether and collected by vacuum filtration to give 2-(morpholin-4-yl)-4-nitro-1H-benzimidazole (288 mg).

Aufarbeitung

  1. extractionextracted with chloroform
  2. washThe organic layer was washed with brine
  3. dry with materialdried over magnesium sulfate
  4. customThe solvent was evaporated in vacuo
  5. washThe residue was washed with isopropyl ether
  6. filtrationcollected by vacuum filtration

Quellen und Nachweise

ORD-Eintrag
ord-1974a1f013ee4591b081c81e72c586ad
Quelldatensatz
uspto-grants-2002_12
Patentnummer
US06495542B1

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