Bromine → Ethyl 6-bromo-6-(4-chlorobenzoyl)hexanoate

HRID 2300669Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2300669
[Br:1]Br.[Cl:3][C:4]1[CH:21]=[CH:20][C:7]([C:8]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[O:9])=[CH:6][CH:5]=1>ClCCl>[Br:1][CH:10]([C:8](=[O:9])[C:7]1[CH:6]=[CH:5][C:4]([Cl:3])=[CH:21][CH:20]=1)[CH2:11][CH2:12][CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 11065929Ethyl 7-(4-chlorophenyl)-7-oxoheptanoate

Produkt 1

HCID 11810554Ethyl 6-bromo-6-(4-chlorobenzoyl)hexanoateAusbeute 99,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Bromine(21.1 g) was added dropwise to a dichloromethane solution (200 ml) of ethyl 6-(4-chlorobenzoyl)hexanoate (37.3 g) at room temperature. After stirring for 30 minutes, the reaction mixture was washed with sodium hydrogensulfite, saturated sodium bicarbonate and water in turn. The dichloromethane layer was dried(MgSO4). The solvent was evaporated to give ethyl 6-bromo-6-(4-chlorobenzoyl)hexanoate(47.6 g, quant.) as an oily substance.

Aufarbeitung

  1. washthe reaction mixture was washed with sodium hydrogensulfite, saturated sodium bicarbonate and water in turn
  2. customThe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-36616594bbb44475a902eccb52f28337
Quelldatensatz
uspto-grants-2002_12
Patentnummer
US06498179B1

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