Hydrochloric Acid → 3-(Diethylsulfamoyl)benzoic acid

HRID 2300765

Reaktionsgleichung

Reaktionsgleichung von HRID 2300765
Cl[S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=1)[C:8]([OH:10])=[O:9])(=[O:4])=[O:3].[CH2:14]([NH:16][CH2:17][CH3:18])[CH3:15].Cl>C(Cl)Cl>[CH2:14]([N:16]([CH2:17][CH3:18])[S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=1)[C:8]([OH:10])=[O:9])(=[O:4])=[O:3])[CH3:15]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 8021DiethylamineHCID 77641Benzoic acid, 3-(chlorosulfonyl)-

Produkt 1

HCID 7945953-(Diethylsulfamoyl)benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

To a solution of 3-(chlorosulfonyl)benzoic acid (1.02 g, 4.62 mmol) in CH2Cl2 (100 mL) at 0° C. was added diethylamine (2.4 mL, 23 mmol). The resulting mixture was stirred at 0° C. for 3 h then worked up by adding 2N aqueous HCl and extracting 3× with EtOAc. The combined organic was washed with brine then dried over MgSO4 and concentrated under reduced pressure. The residue was used without further purification.

Aufarbeitung

  1. extractionextracting 3× with EtOAc
  2. washThe combined organic was washed with brine
  3. dry with materialthen dried over MgSO4
  4. concentrationconcentrated under reduced pressure
  5. customThe residue was used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-90ed747076b34b5eba680df517cd9781
Quelldatensatz
uspto-grants-2002_12
Patentnummer
US06498165B1

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