2-(benzo[1,3]dioxol-5-yl)-3-hydroxy-6-amino-4H-1-benzopyran-4-one → N-[2-(Benzo[1,3]dioxol-5-yl)-3-hydroxy-4-oxo-4H-chromen-6-yl]-N'-cyclohexylsulfamide

HRID 2301348Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2301348
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[O:8][C:7]([C:12]1[CH:20]=[CH:19][C:15]3[O:16][CH2:17][O:18][C:14]=3[CH:13]=1)=[C:6]([OH:21])[C:5]2=[O:22].[CH:23]1([NH:29][S:30](Cl)(=[O:32])=[O:31])[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1>N1C=CC=CC=1.O>[O:16]1[C:15]2[CH:19]=[CH:20][C:12]([C:7]3[O:8][C:9]4[C:4]([C:5](=[O:22])[C:6]=3[OH:21])=[CH:3][C:2]([NH:1][S:30]([NH:29][CH:23]3[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]3)(=[O:32])=[O:31])=[CH:11][CH:10]=4)=[CH:13][C:14]=2[O:18][CH2:17]1

Komponenten

5

Edukt 2

HCID 99262072-(benzo[1,3]dioxol-5-yl)-3-hydroxy-6-amino-4H-1-benzopyran-4-oneHCID 12914615Cyclohexylsulfamyl chloride

Produkt 1

HCID 9804188N-[2-(Benzo[1,3]dioxol-5-yl)-3-hydroxy-4-oxo-4H-chromen-6-yl]-N'-cyclohexylsulfamideAusbeute 13 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 1049PyridineLösungsmittel

Versuchsvorschrift

30 mg (101 pmol) of 6-amino-2-(benzo[1,3]dioxol-5-yl)-3-hydroxy-4H-chromen-4-one obtained in Example 24 was dissolved in 3 ml of pyridine, and the mixture was reacted with excess amount of cyclohexylamino sulfonylchloride at room temperature for 15 hours. After the reaction was completed, the resulting product was diluted with 10 ml of water. The produced solid was filtered, washed with water and ethylether, and then dried to give 6 mg of the title compound in a yield of 13%.

Aufarbeitung

  1. filtrationThe produced solid was filtered
  2. washwashed with water and ethylether
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-2d5fd1ec7dae4b7ba929df081774b53d
Quelldatensatz
uspto-grants-2002_12
Patentnummer
US06500846B1

Notizen zur Reaktion

Wird geladen…