Ethyl pyruvate → N-(3,4Difluorophenyl)alanine Ethyl Ester
Reaktionsgleichung
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[F:9])[NH2:5].[C:10]([O:15][CH2:16][CH3:17])(=[O:14])[C:11]([CH3:13])=O>>[CH2:16]([O:15][C:10](=[O:14])[C@H:11]([CH3:13])[NH:5][C:4]1[CH:6]=[CH:7][C:8]([F:9])=[C:2]([F:1])[CH:3]=1)[CH3:17]Komponenten
3
Versuchsvorschrift
Following General Procedure AA above and using 3,4-difluoroaniline (Aldrich) and ethyl pyruvate (Aldrich), the title compound was prepared. The reaction was monitored by tlc on silica gel (Rf=0.4 in 25% EtOAc/hexanes) and purification was by preparative plate chromatography (silica gel using 25% EtOAc/hexanes as the eluant).
Aufarbeitung
- customThe reaction was monitored by tlc on silica gel (Rf=0.4 in 25% EtOAc/hexanes) and purification
Quellen und Nachweise
- ORD-Eintrag
- ord-5aea20dd2678425ea297ac123bd82da1
- Quelldatensatz
- uspto-grants-2005_02
- Patentnummer
- US06849650B2
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