Ethanol → 8-Hydroxyjulolidine

HRID 2303941

Reaktionsgleichung

Reaktionsgleichung von HRID 2303941
[NH2:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.Br[CH2:10][CH2:11][CH2:12]Cl.[C:14]([O-])(O)=O.[Na+].[CH2:19](O)[CH3:20]>>[CH2:11]1[CH2:12][N:1]2[C:2]3[C:3]([CH2:14][CH2:19][CH2:20]2)=[C:4]([OH:8])[CH:5]=[CH:6][C:7]=3[CH2:10]1

Komponenten

5

Edukt 4

HCID 702EthanolHCID 80061-Bromo-3-chloropropaneHCID 115683-AminophenolHCID 516892Sodium Bicarbonate

Produkt 1

HCID 1704748-HydroxyjulolidineAusbeute 39 %

Versuchsvorschrift

According to a procedure similar to that of Embodiment 5, a mixture of m-aminophenol (5.0 g, 45.8 mmol), 1-bromo-3-chloropropane (23.9 g, 15 ml, 150 mmol) and ethanol (50 ml) was heated and refluxed. NaHCO3 (10.0 g, 119 mmol) aqueous solution (20 ml) was added slowly. After 24 hours of reflux, 3.4 g of 8-hydroxyjulolidine was obtained in 39% yield.

Aufarbeitung

  1. temperaturewas heated
  2. temperaturerefluxed
  3. temperatureAfter 24 hours of reflux

Quellen und Nachweise

ORD-Eintrag
ord-a5fd6cbee54040239240a353d2500eff
Quelldatensatz
uspto-grants-2002_08
Patentnummer
US06433176B1

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