Sodium borohydride → HCID 11047852, Verbindung

HRID 2304559Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2304559
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][C:18]=1[F:19])[N:15]=[C:14]([I:20])[C:13]([CH:21]=[O:22])=[CH:12]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[BH4-].[Na+]>CO>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][C:18]=1[F:19])[N:15]=[C:14]([I:20])[C:13]([CH2:21][OH:22])=[CH:12]2)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 4311764Sodium borohydrideHCID 22987158HCID 22987158, Verbindung

Produkt 1

HCID 11047852HCID 11047852, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A suspension of 6-benzyloxy-7-fluoro-2-iodo-3-quinolinecarbaldehyde (obtained according to 1.e, 13 g, 32 mmol) in methanol (100 ml) is treated with sodium borohydride (1.85 g, 48 mmol). After 1 hour of reaction, the reaction medium is concentrated under reduced pressure then taken up with water, filtered, washed with water and ethanol in order to produce, after drying under reduced pressure, 10 g (76%) of a white solid, m.p. 188° C.

Aufarbeitung

  1. customAfter 1 hour of reaction
  2. concentrationthe reaction medium is concentrated under reduced pressure
  3. filtrationfiltered
  4. washwashed with water and ethanol in order
  5. customto produce
  6. dry with materialafter drying under reduced pressure, 10 g (76%) of a white solid, m.p. 188° C.

Quellen und Nachweise

ORD-Eintrag
ord-ea7d5449aba440ba9a6ce7d826699629
Quelldatensatz
uspto-grants-2002_08
Patentnummer
US06436951B1

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