Potassium Hydroxide → Octyl-sepharose CL-4B

Temperatur

140 °C

In an autoclave, 208 g of the resulting crude octyl glycidyl ether, 104.8 g of water, 5.82 g of lauric acid and 18.5 g of potassium hydroxide were charged. The resulting mixture was stirred at 140° C. for 5 hours. The reaction mixture was dehydrated at 100° C. under reduced pressure (6.67 kPa), followed by the addition of 9.7 g of lauric acid and 2.72 g of potassium hydroxide. After reaction at 160° C. for 15 hours, the reaction mixture was purified by distillation under reduced pressure (53 to 67 Pa, 120 to 123° C.), whereby 110.2 g of monooctyl glyceryl ether was obtained. As a result of GLC, it was found that the resulting product had a purity not less than 99% and the content of organochlorine compounds was not greater than 100 ppm.

1. customwas dehydrated at 100° C. under reduced pressure (6.67 kPa)
2. customAfter reaction at 160° C. for 15 hours
3. distillationthe reaction mixture was purified by distillation under reduced pressure (53 to 67 Pa, 120 to 123° C.)

ORD-Eintrag

ord-9438a06d833a496cb74ff02deab5d5e1

Quelldatensatz

uspto-grants-2002_08

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06437196B1