Lactic Acid → beta-sitosterol Lactate

HRID 2306120

Reaktionsgleichung

Reaktionsgleichung von HRID 2306120
[CH3:1][CH2:2][C@@H:3]([CH:28]([CH3:30])[CH3:29])[CH2:4][CH2:5][C@H:6]([C@@H:8]1[C@@:12]2([CH3:27])[CH2:13][CH2:14][C@@H:15]3[C@@:20]4([CH3:26])[CH2:21][CH2:22][C@H:23]([OH:25])[CH2:24][C:19]4=[CH:18][CH2:17][C@H:16]3[C@@H:11]2[CH2:10][CH2:9]1)[CH3:7].[C:31]([OH:36])(=[O:35])[CH:32]([CH3:34])[OH:33].C1(C)C=CC=CC=1>O>[CH3:1][CH2:2][C@@H:3]([CH:28]([CH3:29])[CH3:30])[CH2:4][CH2:5][C@H:6]([C@@H:8]1[C@@:12]2([CH3:27])[CH2:13][CH2:14][C@@H:15]3[C@@:20]4([CH3:26])[CH2:21][CH2:22][C@H:23]([OH:25])[CH2:24][C:19]4=[CH:18][CH2:17][C@H:16]3[C@@H:11]2[CH2:10][CH2:9]1)[CH3:7].[C:31]([O-:36])(=[O:35])[CH:32]([CH3:34])[OH:33]

Komponenten

5

Edukt 3

HCID 612Lactic AcidHCID 1140TolueneHCID 222284(-)-beta-Sitosterol

Produkt 1

HCID 86758485beta-sitosterol Lactate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

200 g β-sitosterol, 250 g lactic acid, and 500 ml toluene were dissolved in a 5 l flask. The mixture was refluxed at 110-115° C. at the same time as water (free water+reaction water) was collected using water separation apparatus, in order to monitor the progress of the reaction. Reaction time was 11.5 h. At this point, 68 ml of water had been collected (free water: 33.8 ml+reaction water 34.2 ml), representing a 77.5% conversion in relation to the starting material. The toluene was evaporated from the reaction mixture using a rotavapor, and the product was dried in a vacuum oven at 40-60° C. The esterification experiment was repeated 5 times.

Aufarbeitung

  1. customwas collected
  2. customwater separation apparatus
  3. customthe progress of the reaction
  4. customReaction time
  5. customAt this point, 68 ml of water had been collected
  6. custom(free water: 33.8 ml+reaction water 34.2 ml)
  7. customThe toluene was evaporated from the reaction mixture
  8. customthe product was dried in a vacuum oven at 40-60° C

Quellen und Nachweise

ORD-Eintrag
ord-fbea81868c184d6897ee545c557b3c4b
Quelldatensatz
uspto-grants-2002_08
Patentnummer
US06441206B1

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