Ethanol → HCID 136347709, Verbindung

HRID 2306660Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2306660
[C:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][C:5]=1[OH:14])(=O)[CH3:2].CCO.Cl.[NH2:19][OH:20]>[OH-].[Na+]>[OH:14][C:5]1[CH:6]=[C:7]([CH:12]=[CH:13][C:4]=1[C:1](=[N:19][OH:20])[CH3:2])[C:8]([O:10][CH3:11])=[O:9]

Komponenten

5

Edukt 3

HCID 702EthanolHCID 443297Hydroxyamine hydrochlorideHCID 22610067Methyl 4-acetyl-3-hydroxybenzoate

Produkt 1

HCID 136347709HCID 136347709, VerbindungAusbeute 78,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

Methyl 4-acetyl-3-hydroxybenzoate (350 mg, 1.8 mmole) is combined with 5 ml absolute EtOH. The solution is treated with hydroxylamine hydrochloride (125 mg, 1.8 mmole) dissolved in 0.9 ml 2N aqueous NaOH, and the reaction is stirred overnight at rt. The volatiles are removed in vacuo and the residue is washed with H2O, collected, and dried to give 294 mg (78%) of methyl 3-hydroxy-4-[N-hydroxyethanimidoyl]benzoate as a tan solid. MS (EI) m/z: 209 (M+).

Aufarbeitung

  1. customThe volatiles are removed in vacuo
  2. washthe residue is washed with H2O
  3. customcollected
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-21289b0afe6342acbdf4645abada056c
Quelldatensatz
uspto-grants-2004_12
Patentnummer
US06828330B2

Notizen zur Reaktion

Wird geladen…