Hydrochloric Acid → 239113-23-6

HRID 2306856Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2306856
[Cl:1][C:2]1[C:3]([CH:12]([N:20]=C(C2C=CC=CC=2)C2C=CC=CC=2)[CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.Cl>C(OCC)C>[ClH:1].[Cl:1][C:2]1[C:3]([CH:12]([NH2:20])[CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:9])[F:10])[CH:7]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 22629930HCID 22629930, Verbindung

Produkt 1

HCID 69351932239113-23-6

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To a solution of the product from stage b) (1.29 g) in diethyl ether (5 ml) was added 1M hydrochloric acid (10 ml) at room temperature and the solution was stirred at room temperature for 2 hours. The mixture was filtered to give a solid, which was washed with water (15 ml) then ether (15 ml). Drying in vacuo gave the title product. Water was removed from the aqueous phase by azeotropic distillation with toluene (×3), to give further quantities of the title product.

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. customto give a solid, which
  3. washwas washed with water (15 ml)
  4. customDrying in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-bb3e168c11bd4080b841a93b67be50ad
Quelldatensatz
uspto-grants-2004_12
Patentnummer
US06828441B2

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