HCID 22176515, Verbindung → HCID 22176470, Verbindung
Reaktionsgleichung
[Br:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[C:4]([CH2:11][CH3:12])[N+:3]=1[O-]>C(O)(=O)C.[Fe]>[Br:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[C:4]([CH2:11][CH3:12])[N:3]=1Komponenten
4
Reagenzien, Katalysatoren, Lösungsmittel 2
Reaktionsbedingungen
- Temperatur
- 100 °C
Versuchsvorschrift
A solution of 2-bromo-6-ethyl-4-nitro-pyridine 1-oxide (example 5b) (15.9 g, 69 mmol) in acetic acid (310 ml) was treated with powdered iron (25.8 g, 462 mmol). The mixture was slowly heated to 100° C. and kept for 1 hr at this temperature. Then the reaction mixture was cooled to rt and filtered. After evaporation of the solvent the residue was crystallized to yield the title compound as a beige material (88%). Mp. 75-77° C. (pentane), MS: m/e=200 (M+).
Aufarbeitung
- temperatureThen the reaction mixture was cooled to rt
- filtrationfiltered
- customAfter evaporation of the solvent the residue
- customwas crystallized
Quellen und Nachweise
- ORD-Eintrag
- ord-a7269623d10b431a89cebff5584cc744
- Quelldatensatz
- uspto-grants-2004_12
- Patentnummer
- US06831087B2
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