N-(5-Chloro-3-methylidene-2,3-dihydro-1-benzofuran-4-yl)-2,2,2-trifluoroacetamide → 2,2,2-Trifluoro-N-(3-methyl-2,3-dihydro-1-benzofuran-4-yl)acetamide

HRID 230848

Reaktionsgleichung

Reaktionsgleichung von HRID 230848
Cl[C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH2:8][C:7](=[CH2:10])[C:6]=2[C:11]=1[NH:12][C:13](=[O:18])[C:14]([F:17])([F:16])[F:15]>C(O)C.[Pd]>[F:17][C:14]([F:15])([F:16])[C:13]([NH:12][C:11]1[C:6]2[CH:7]([CH3:10])[CH2:8][O:9][C:5]=2[CH:4]=[CH:3][CH:2]=1)=[O:18]

Komponenten

4

Edukt 1

HCID 57763270N-(5-Chloro-3-methylidene-2,3-dihydro-1-benzofuran-4-yl)-2,2,2-trifluoroacetamide

Produkt 1

HCID 577632852,2,2-Trifluoro-N-(3-methyl-2,3-dihydro-1-benzofuran-4-yl)acetamideAusbeute 104,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of Intermediate 23 (0.10 g) in ethanol (20 ml) was added to 10% palladium on carbon (0.20 g) and the mixture stirred under an atmosphere of hydrogen for 20 h. The mixture was filtered through ‘hyflo’ filter aid, washed with ethanol and the solvent removed in vacuo to give the title compound as a white solid (0.092 g).

Aufarbeitung

  1. filtrationThe mixture was filtered through ‘hyflo’
  2. filtrationfilter aid
  3. washwashed with ethanol
  4. customthe solvent removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-07a50bda887847c5a08ffd5d164601dd
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07566786B2

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