Water → 1-[2-(Benzyloxy)-6-hydroxyphenyl]ethan-1-one

HRID 230869

Reaktionsgleichung

Reaktionsgleichung von HRID 230869
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([OH:8])[C:3]=1[C:9](=[O:11])[CH3:10].C(=O)([O-])[O-].[K+].[K+].[CH2:18](Br)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.O>CC(C)=O>[CH2:18]([O:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([OH:8])[C:3]=1[C:9](=[O:11])[CH3:10])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 696872',6'-Dihydroxyacetophenone

Produkt 1

HCID 27751871-[2-(Benzyloxy)-6-hydroxyphenyl]ethan-1-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

To a mixture of 2′,6′-dihydroxyacetophenone (4 g) and potassium carbonate (3.82 g) in acetone (40 mL) was added benzyl bromide (3.13 mL), and the mixture was stirred at room temperature overnight. The reaction mixture was poured into water, and the precipitated crystals were collected by filtration. The crystals were washed with water and n-hexane, and dried under reduced pressure to give the title compound (3.67 g).

Aufarbeitung

  1. filtrationthe precipitated crystals were collected by filtration
  2. washThe crystals were washed with water and n-hexane
  3. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-ad510b46ab0447c5abe0f9bfcbc6058e
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07566699B2

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