Water → 6'-Hydroxy-2'-(methoxycarbonylmethoxy)acetophenone

HRID 230893

Reaktionsgleichung

Reaktionsgleichung von HRID 230893
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([OH:8])[C:3]=1[C:9](=[O:11])[CH3:10].C(=O)([O-])[O-].[K+].[K+].Br[CH2:19][C:20]([O:22][CH3:23])=[O:21].O>CC(C)=O>[OH:1][C:2]1[C:3]([C:9](=[O:11])[CH3:10])=[C:4]([O:8][CH2:19][C:20]([O:22][CH3:23])=[O:21])[CH:5]=[CH:6][CH:7]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 696872',6'-Dihydroxyacetophenone

Produkt 1

HCID 105370846'-Hydroxy-2'-(methoxycarbonylmethoxy)acetophenone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

To a mixture of 2′,6′-dihydroxyacetophenone (6 g) and potassium carbonate (5.72 g) in acetone (20 mL) was added methyl bromoacetate (3.73 mL), and the mixture was stirred at room temperature for 5 days. To the reaction mixture was added water, and the precipitated crystals were collected by filtration. The crystals were washed with water and dried under reduced pressure to give the title compound (7.89 g).

Aufarbeitung

  1. filtrationthe precipitated crystals were collected by filtration
  2. washThe crystals were washed with water
  3. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-9697439f8c5f4eaf8fdafdd370708a5d
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07566699B2

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