Water → Bacitracin Manganese Lysocellin

HRID 2309222

Reaktionsgleichung

Reaktionsgleichung von HRID 2309222
[Mn:1].[CH3:2][CH2:3][C@@H:4]([C:25]([C@H:27]([C@@H:29]([OH:45])[C@H:30]([C@H:32]1[O:37][C@@H:36]([CH2:38][C:39]([O:41][OH:42])=[O:40])[C@H:35]([CH3:43])[CH2:34][C@@H:33]1[CH3:44])[CH3:31])[CH3:28])=[O:26])[C@H:5]1[O:9][C@@:8]([C@:11]2([OH:23])[O:15][C@@:14]([C@@H:18]([OH:21])[CH2:19][CH3:20])([CH2:16][CH3:17])[CH2:13][C@H:12]2[CH3:22])([CH3:10])[CH2:7][C@@H:6]1[CH3:24].[CH3:46][CH2:47][C@@H:48]([C@@H:50]1[NH:81][C:79](=[O:80])[C@@H:78]([CH2:82][CH2:83][CH2:84][NH2:85])[NH:77][C:75](=[O:76])[C@@H:74]([NH:86][C:87]([C@@H:89]([NH:94][C:95]([C@H:97]([NH:103][C:104]([C@@H:106]([NH:111][C:112]([C@H:114]2[N:118]=[C:117]([C@@H:119]([NH2:124])[C@H:120]([CH2:122][CH3:123])[CH3:121])[S:116][CH2:115]2)=[O:113])[CH2:107][CH:108]([CH3:110])[CH3:109])=[O:105])[CH2:98][CH2:99][C:100]([OH:102])=[O:101])=[O:96])[C@H:90]([CH2:92][CH3:93])[CH3:91])=[O:88])[CH2:73][CH2:72][CH2:71][CH2:70][NH:69][C:67](=[O:68])[C@H:66]([CH2:125][C:126]([NH2:128])=[O:127])[NH:65][C:63](=[O:64])[C@@H:62]([CH2:129][C:130]([OH:132])=[O:131])[NH:61][C:59](=[O:60])[C@H:58]([CH2:133][C:134]2[NH:138][CH:137]=[N:136][CH:135]=2)[NH:57][C:55](=[O:56])[C@@H:54]([CH2:139][C:140]2[CH:141]=[CH:142][CH:143]=[CH:144][CH:145]=2)[NH:53][C:51]1=[O:52])[CH3:49].O>CO>[CH3:46][CH2:47][C@@H:48]([C@@H:50]1[NH:81][C:79](=[O:80])[C@@H:78]([CH2:82][CH2:83][CH2:84][NH2:85])[NH:77][C:75](=[O:76])[C@@H:74]([NH:86][C:87]([C@@H:89]([NH:94][C:95]([C@H:97]([NH:103][C:104]([C@@H:106]([NH:111][C:112]([C@H:114]2[N:118]=[C:117]([C@@H:119]([NH2:124])[C@H:120]([CH2:122][CH3:123])[CH3:121])[S:116][CH2:115]2)=[O:113])[CH2:107][CH:108]([CH3:109])[CH3:110])=[O:105])[CH2:98][CH2:99][C:100]([OH:102])=[O:101])=[O:96])[C@H:90]([CH2:92][CH3:93])[CH3:91])=[O:88])[CH2:73][CH2:72][CH2:71][CH2:70][NH:69][C:67](=[O:68])[C@H:66]([CH2:125][C:126]([NH2:128])=[O:127])[NH:65][C:63](=[O:64])[C@@H:62]([CH2:129][C:130]([OH:132])=[O:131])[NH:61][C:59](=[O:60])[C@H:58]([CH2:133][C:134]2[NH:138][CH:137]=[N:136][CH:135]=2)[NH:57][C:55](=[O:56])[C@@H:54]([CH2:139][C:140]2[CH:141]=[CH:142][CH:143]=[CH:144][CH:145]=2)[NH:53][C:51]1=[O:52])[CH3:49].[Mn:1].[CH3:2][CH2:3][C@@H:4]([C:25]([C@H:27]([C@@H:29]([OH:45])[C@H:30]([C@H:32]1[O:37][C@@H:36]([CH2:38][C:39]([O:41][OH:42])=[O:40])[C@H:35]([CH3:43])[CH2:34][C@@H:33]1[CH3:44])[CH3:31])[CH3:28])=[O:26])[C@H:5]1[O:9][C@@:8]([C@:11]2([OH:23])[O:15][C@@:14]([C@@H:18]([OH:21])[CH2:19][CH3:20])([CH2:16][CH3:17])[CH2:13][C@H:12]2[CH3:22])([CH3:10])[CH2:7][C@@H:6]1[CH3:24]

Komponenten

5

Edukt 3

HCID 962WaterHCID 10909430BacitracinHCID 86741789Manganese Lysocellin

Produkt 1

HCID 86741796Bacitracin Manganese Lysocellin

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 6.5 g of manganese lysocellin, prepared as described in Example D above, in 60 ml of methanol was stirred while 7.0 g bacitracin (reg) was added. The solution was stirred at room temperature for four hours. Stirring was continued and water was added slowly to precipitate a tacky semi-solid. The solids were isolated by decantation and washed with fresh water to obtain a filtrable amorphous solid. The solids were isolated, washed with water and dried. The crude product was slurried with toluene (10 ml/g) to obtain an amorphous product.

Aufarbeitung

  1. additionwas added
  2. stirringStirring
  3. customto precipitate a tacky semi-solid
  4. customThe solids were isolated by decantation
  5. washwashed with fresh water
  6. customto obtain a filtrable amorphous solid
  7. customThe solids were isolated
  8. washwashed with water
  9. customdried
  10. customto obtain an amorphous product

Quellen und Nachweise

ORD-Eintrag
ord-9750d0795f3d48a9aea2cd33e06a3bd5
Quelldatensatz
uspto-grants-1987_09
Patentnummer
US04693992

Verknüpfte Notizen

Wird geladen…