Einecs 211-027-4 → 2,6-Dimethyl-4-(3-methyl-1H-indol-2-yl)phenol

HRID 2309404

Reaktionsgleichung

Reaktionsgleichung von HRID 2309404
C[O:2][C:3]1[C:8]([CH3:9])=[CH:7][C:6]([C:10]2[NH:11][C:12]3[C:17]([C:18]=2[CH3:19])=[CH:16][CH:15]=[CH:14][CH:13]=3)=[CH:5][C:4]=1[CH3:20].[Cl-].[NH+]1C=CC=CC=1>O>[OH:2][C:3]1[C:4]([CH3:20])=[CH:5][C:6]([C:10]2[NH:11][C:12]3[C:17]([C:18]=2[CH3:19])=[CH:16][CH:15]=[CH:14][CH:13]=3)=[CH:7][C:8]=1[CH3:9]

Komponenten

4

Edukt 2

HCID 69401Einecs 211-027-4HCID 136701412-(4-Methoxy-3,5-dimethylphenyl)-3-methylindole

Produkt 1

HCID 136701422,6-Dimethyl-4-(3-methyl-1H-indol-2-yl)phenolAusbeute 63,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

4.3 g of 2-(4-methoxy-3,5-dimethylphenyl)-3-methylindole and 13 g of pyridinium chloride were reacted at 200° C. for 1.5 hours. The reaction mixture was cooled, poured into water, extracted with ethyl acetate, washed with water, and dried. The solvent was evaporated, and the residue was recrystallized from benzene-hexane to give 2.6 g of 2-(4-hydroxy-3,5-dimethylphenyl)-3-methylindole.

Aufarbeitung

  1. temperatureThe reaction mixture was cooled
  2. extractionextracted with ethyl acetate
  3. washwashed with water
  4. customdried
  5. customThe solvent was evaporated
  6. customthe residue was recrystallized from benzene-hexane

Quellen und Nachweise

ORD-Eintrag
ord-b3a29044874c44b495ff169bdfa34147
Quelldatensatz
uspto-grants-1987_09
Patentnummer
US04695581

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