Diazomethane → Methyl 7-(2-oxocyclopentyl)heptanoate

HRID 2309559Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2309559
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][CH:3]1[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14].[N+](=[CH2:18])=[N-]>CCOCC>[CH3:18][O:14][C:13](=[O:15])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH:3]1[CH2:4][CH2:5][CH2:6][C:2]1=[O:1]

Komponenten

4

Edukt 2

HCID 9550DiazomethaneHCID 989472-Oxocyclopentaneheptanoic acid

Produkt 1

HCID 13099223Methyl 7-(2-oxocyclopentyl)heptanoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

A 2.14 g. portion of 7-(2-oxocyclopentyl)-heptanoic acid was dissolved in 20 ml. of anhydrous ether and cooled to 0° C. in an ice bath. The stirred solution was then treated with ethereal diazomethane in about 1 ml. portions to control gas evolution until the yellow color persisted and bubbling was slow. The excess reagent was then blown off with a stream of nitrogen and the solvent evaporated at the rotovap. The residual oily ester was dried in vacuo over phosphorous pentoxide.

Aufarbeitung

  1. custombubbling
  2. customthe solvent evaporated at the rotovap
  3. dry with materialThe residual oily ester was dried in vacuo over phosphorous pentoxide

Quellen und Nachweise

ORD-Eintrag
ord-3f7f559b05714d5a81aa4dcef06c6133
Quelldatensatz
uspto-grants-1987_09
Patentnummer
US04695647

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