Methanesulfonyl chloride → HCID 13284512, Verbindung

HRID 2309890Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2309890
Cl.Cl.[CH3:3][N:4]([CH3:21])[C:5]1[CH:10]=[C:9]([NH2:11])[CH:8]=[CH:7][C:6]=1[C:12]1[NH:13][C:14]2[C:15]([N:20]=1)=[N:16][CH:17]=[CH:18][CH:19]=2.[CH3:22][S:23](Cl)(=[O:25])=[O:24]>N1C=CC=CC=1>[CH3:3][N:4]([CH3:21])[C:5]1[CH:10]=[C:9]([NH:11][S:23]([CH3:22])(=[O:25])=[O:24])[CH:8]=[CH:7][C:6]=1[C:12]1[NH:13][C:14]2[C:15]([N:20]=1)=[N:16][CH:17]=[CH:18][CH:19]=2

Komponenten

4

Edukt 2

HCID 31297Methanesulfonyl chlorideHCID 20184547HCID 20184547, Verbindung

Produkt 1

HCID 13284512HCID 13284512, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

An amount of 0.49 gm 2-(2'-dimethylamino-4'-aminophenyl)-imidazo[4,5-b]pyridine dihydrochloride was dissolved in 10 ml of pyridine, 0.38 gm of methanesulfonyl chloride were added dropwise, and the mixture was stirred for two days at ambient temperature. The reaction mixture was poured onto water, and the solution obtained was extracted with ethyl acetate. The ethyl acetate phases were washed with common salt solution and concentrated by evaporation. The residue was triturated with 2N acetic acid, subjected to filtration, and washed with water.

Aufarbeitung

  1. additionThe reaction mixture was poured onto water
  2. customthe solution obtained
  3. extractionwas extracted with ethyl acetate
  4. washThe ethyl acetate phases were washed with common salt solution
  5. concentrationconcentrated by evaporation
  6. customThe residue was triturated with 2N acetic acid
  7. filtrationsubjected to filtration
  8. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-950efe23944e4a03a14e23086bc5c559
Quelldatensatz
uspto-grants-1987_09
Patentnummer
US04696931

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