Water → 10-acetyl-4-chloro-3-hydroxy-10H-phenothiazine

HRID 231049Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 231049
[Cl:1][C:2]1[C:15]2[S:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[NH:7][C:6]=2[CH:5]=[CH:4][C:3]=1[OH:16].[C:17](Cl)(=[O:19])[CH3:18].C(OCC)(=O)C.O>CN(C=O)C>[C:17]([N:7]1[C:6]2[CH:5]=[CH:4][C:3]([OH:16])=[C:2]([Cl:1])[C:15]=2[S:14][C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2)(=[O:19])[CH3:18]

Komponenten

6

Edukt 4

HCID 962WaterHCID 6367Acetyl chlorideHCID 8857Ethyl AcetateHCID 98814184-chloro-3-hydroxy-10H-phenothiazine

Produkt 1

HCID 1388203310-acetyl-4-chloro-3-hydroxy-10H-phenothiazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a solution of 4-chloro-3-hydroxyphenothiazine (2.2 g) in DMF (10 ml) was added 10 ml of acetyl chloride. The reaction mixture was stirred at ambient temperature for 1 hour. Ethyl acetate was then added, followed by ice and H2O. The organic layer was separated, dried and evaporated. The resulting residue was purified by chromatography on silica gel to give 1.4 g of 10-acetyl-4-chloro-3-hydroxy-10H-phenothiazine (m.p. 214° C.).

Aufarbeitung

  1. customThe organic layer was separated
  2. customdried
  3. customevaporated
  4. customThe resulting residue was purified by chromatography on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-1c5ba483752c45b6afffabc345b90f0c
Quelldatensatz
uspto-grants-1989_07
Patentnummer
US04845083

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