Water → N-([(4-Bromophenyl)amino]carbonyl)-4-methoxybenzenesulfonamide

HRID 231135

Reaktionsgleichung

Reaktionsgleichung von HRID 231135
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([NH2:12])(=[O:11])=[O:10])=[CH:5][CH:4]=1.[OH-].[Na+].[Br:15][C:16]1[CH:21]=[CH:20][C:19]([N:22]=[C:23]=[O:24])=[CH:18][CH:17]=1.O>CC(C)=O>[Br:15][C:16]1[CH:21]=[CH:20][C:19]([NH:22][C:23]([NH:12][S:9]([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)(=[O:11])=[O:10])=[O:24])=[CH:18][CH:17]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 707894-MethoxybenzenesulfonamideHCID 756094-Bromophenyl isocyanate

Produkt 1

HCID 14480021N-([(4-Bromophenyl)amino]carbonyl)-4-methoxybenzenesulfonamideAusbeute 91,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel2×

Versuchsvorschrift

To a solution of 9.97 g of 4-methoxybenzenesulfonamide in 54 ml of acetone were added 54 ml of a 1N sodium hydroxide solution. With stirring, a solution of 11.55 g of 4-bromophenylisocyanate in 50 ml of acetone was added. After stirring at room temperature for three days, the reaction mixture was filtered and 55 ml of 1N hydrochloric acid were added to the filtrate providing a fine white precipitate. Two hundred milliliters of water were added, and the solid was recovered by filtration to provide 18.85 g of the desired title product.

Aufarbeitung

  1. stirringAfter stirring at room temperature for three days
  2. filtrationthe reaction mixture was filtered
  3. addition55 ml of 1N hydrochloric acid were added to the filtrate
  4. customproviding a fine white precipitate
  5. filtrationthe solid was recovered by filtration

Quellen und Nachweise

ORD-Eintrag
ord-c4993c3210e545c4affc8802d81baeb4
Quelldatensatz
uspto-grants-1989_07
Patentnummer
US04845128

Verknüpfte Notizen

Wird geladen…