Triethylamine → 3-Mesyloxypropyl 2-methoxy-3-(12-cyclohexyldodecyloxy)propyl sulfone

HRID 231272Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 231272
[OH:1][CH2:2][CH2:3][CH2:4][S:5]([CH2:8][CH:9]([O:30][CH3:31])[CH2:10][O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH:24]1[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1)(=[O:7])=[O:6].C(N(CC)CC)C.[CH3:39][S:40](Cl)(=[O:42])=[O:41]>ClCCl>[CH3:31][O:30][CH:9]([CH2:10][O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH:24]1[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]1)[CH2:8][S:5]([CH2:4][CH2:3][CH2:2][O:1][S:40]([CH3:39])(=[O:42])=[O:41])(=[O:7])=[O:6]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 536553312-Methoxy-3-(12-cyclohexyldodecyloxy)propyl 3-hydroxypropyl sulfone

Produkt 1

HCID 200348483-Mesyloxypropyl 2-methoxy-3-(12-cyclohexyldodecyloxy)propyl sulfoneAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

In 100 ml of dichloromethane are dissolved 8.9 g of 2-methoxy-3-(12-cyclohexyldodecyloxy)propyl 3-hydroxypropyl sulfone and 3.7 ml of triethylamine, to which 3.0 g of methanesulfonyl chloride is added dropwise with stirring under ice cooling. After 2 hours stirring at room temperature, the reaction solution is washed with water, an aqueous sodium bicarbonate solution and water, and dried. The solvent is then distilled off under reduced pressure to leave 10.4 g of the captioned compound.

Aufarbeitung

  1. stirringAfter 2 hours stirring at room temperature
  2. washthe reaction solution is washed with water
  3. dry with materialan aqueous sodium bicarbonate solution and water, and dried
  4. distillationThe solvent is then distilled off under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-7b72b371a23642eb80240b8937b93466
Quelldatensatz
uspto-grants-1989_07
Patentnummer
US04845219

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