2-Chloro-4-fluoro-5-nitrotoluene → 4-Chloro-2-fluoro-5-methylaniline

HRID 231407

Reaktionsgleichung

Reaktionsgleichung von HRID 231407
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([N+:9]([O-])=O)=[CH:4][C:3]=1[CH3:12].[H][H]>C(O)(=O)C.[Pt]>[Cl:1][C:2]1[C:3]([CH3:12])=[CH:4][C:5]([NH2:9])=[C:6]([F:8])[CH:7]=1

Komponenten

5

Edukt 2

HCID 101039792-Chloro-4-fluoro-5-nitrotolueneHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 141574954-Chloro-2-fluoro-5-methylaniline

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23939PlatinumKatalysatorHCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A solution of 2-chloro-4-fluoro-5-nitrotoluene (30.0 g, 0.158 mole) in glacial acetic acid (150 ml) was added to a 250 ml Parr bottle which contained platinum IV oxide (0.4 g). The Parr bottle was placed on a Parr hydrogenation apparatus and charged with hydrogen. The reaction mixture was allowed to shake until hydrogen absorption ceased. The catalyst was removed by vacuum filtration. The filtrate containing 4-chloro-2-fluoro-5-methylaniline was used in the following step. This reaction was repeated several times.

Aufarbeitung

  1. customto shake until hydrogen absorption
  2. customThe catalyst was removed by vacuum filtration
  3. additionThe filtrate containing 4-chloro-2-fluoro-5-methylaniline

Quellen und Nachweise

ORD-Eintrag
ord-9b0c3425db194681af283128da57f87f
Quelldatensatz
uspto-grants-1989_07
Patentnummer
US04846875

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