Tetramethoxypropane → Ethyl pyrazolo(1,5-a)pyrimidine-3-carboxylate
Reaktionsgleichung
[NH2:1][C:2]1[NH:6][N:5]=[CH:4][C:3]=1[C:7]([O:9][CH2:10][CH3:11])=[O:8].CO[CH:14](OC)[CH2:15][CH:16](OC)OC>C(O)(=O)C>[N:5]1[N:6]2[CH:14]=[CH:15][CH:16]=[N:1][C:2]2=[C:3]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH:4]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A stirred mixture of 10.88 g of 5-amino-4-pyrazolecarboxylic acid, ethyl ester, 11.51 g of malonaldehyde bis(dimethyl acetal) and 100 ml of glacial acetic acid was heated at reflux for 16 hours, then worked up as described in Example 50 to give 7.8 g of pyrazolo[1,5-a]pyrimidine-3-carboxylic acid, ethyl ester.
Aufarbeitung
- temperaturewas heated
- temperatureat reflux for 16 hours
Quellen und Nachweise
- ORD-Eintrag
- ord-5f8b8cdbe5c44c21aa1db52de5971b43
- Quelldatensatz
- uspto-grants-1989_07
- Patentnummer
- US04847256
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