2-Chloropyridine → 3-[4-(Pyridin-2-yl) piperazin-1-yl]propane-1,2-diol dihydrochloride
Reaktionsgleichung
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[OH:8][CH:9]([CH2:17][OH:18])[CH2:10][N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1>>[ClH:1].[ClH:1].[N:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[N:14]1[CH2:13][CH2:12][N:11]([CH2:10][CH:9]([OH:8])[CH2:17][OH:18])[CH2:16][CH2:15]1Komponenten
3
Versuchsvorschrift
Operation was carried out in a manner similar to the one previously described, using 2-chloropyridine and 1-(2,3-dihydroxypropyl) piperazine. The residue obtained after evaporation to dryness was dissolved in a small amount of concentrated hydrochloric acid and diluted with isopropanol. After resting, 3-[4-(pyridin-2-yl) piperazin-1-yl]propane-1,2-diol dihydrochloride melting at 238°-242° C., was obtained with the 53.6% yield.
Aufarbeitung
- customThe residue obtained
- customafter evaporation to dryness
- dissolution