2-Chloronicotinic acid → 2-[4-(2-Hydroxypropyl)piperazin-1-yl]nicotinic acid

HRID 231774

Reaktionsgleichung

Reaktionsgleichung von HRID 231774
[OH:1][CH:2]([CH3:10])[CH2:3][N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1.Cl[C:12]1[N:20]=[CH:19][CH:18]=[CH:17][C:13]=1[C:14]([OH:16])=[O:15]>O1CCOCC1>[OH:1][CH:2]([CH3:10])[CH2:3][N:4]1[CH2:9][CH2:8][N:7]([C:12]2[N:20]=[CH:19][CH:18]=[CH:17][C:13]=2[C:14]([OH:16])=[O:15])[CH2:6][CH2:5]1

Komponenten

4

Edukt 2

HCID 762582-Chloronicotinic acidHCID 258198alpha-Methyl-1-piperazineethanol

Produkt 1

HCID 200320002-[4-(2-Hydroxypropyl)piperazin-1-yl]nicotinic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

Grams 3 of 1-(2-hydroxypropyl)piperazine and 1.6 g of 2-chloronicotinic acid in 50 ml dioxane were refluxed for 2 days. The react ion mixture was cooled, then allowed to rest for 2 days, the solvent was removed and the residue was crystallized from absolute ethanol to give 1.2 g of 2-[4-(2-hydroxypropyl)piperazin-1-yl]nicotinic acid, melting at 222°-223° C. (with decomposition).

Aufarbeitung

  1. temperatureThe react ion mixture was cooled
  2. customthe solvent was removed
  3. customthe residue was crystallized from absolute ethanol

Quellen und Nachweise

ORD-Eintrag
ord-8296e3fc1a37408dbfc29642a5e33d9f
Quelldatensatz
uspto-grants-1989_07
Patentnummer
US04849422

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