2-Chloronicotinic acid → 2-[4-(2-Hydroxypropyl)piperazin-1-yl]nicotinic acid
Reaktionsgleichung
[OH:1][CH:2]([CH3:10])[CH2:3][N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1.Cl[C:12]1[N:20]=[CH:19][CH:18]=[CH:17][C:13]=1[C:14]([OH:16])=[O:15]>O1CCOCC1>[OH:1][CH:2]([CH3:10])[CH2:3][N:4]1[CH2:9][CH2:8][N:7]([C:12]2[N:20]=[CH:19][CH:18]=[CH:17][C:13]=2[C:14]([OH:16])=[O:15])[CH2:6][CH2:5]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Grams 3 of 1-(2-hydroxypropyl)piperazine and 1.6 g of 2-chloronicotinic acid in 50 ml dioxane were refluxed for 2 days. The react ion mixture was cooled, then allowed to rest for 2 days, the solvent was removed and the residue was crystallized from absolute ethanol to give 1.2 g of 2-[4-(2-hydroxypropyl)piperazin-1-yl]nicotinic acid, melting at 222°-223° C. (with decomposition).